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T-Lymphocyte Variant of Hairy-Cell Leukemia

[+] Article, Author, and Disclosure Information

Grant support: by United States Public Health Service Grants CA 12800, 15619, 15688, and National Institutes of Health Training Grant AI 00431.

▸Requests for reprints should be addressed to David Golde, M.D.; Department of Medicine, UCLA School of Medicine; Los Angeles, CA 90024.

Los Angeles, California

© 1978 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1978;88(3):323-326. doi:10.7326/0003-4819-88-3-323
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Immunohematologic studies on cells from a patient with the clinicopathologic syndrome of hairy-cell leukemia showed that the neoplastic cells had receptors for sheep erythrocytes and therefore had human-T-lymphocyte characteristics. The leukemic cells did not have the membrane receptors or immunoglobulin markers of B lymphocytes or monocytes nor did they synthesize immunoglobulin. A lymphoid cell line established in vitro from the cells had the same T-lymphocyte characteristics. The lymphoid cell line is positive for tartrateresistant acid phosphatase, forms rosettes with untreated sheep erythrocytes, and reacts with an anti-T-lymphocyte antiserum. Thus the syndrome of hairy-cell leukemia may occasionally result from the neoplastic proliferation of T lymphocytes as well as from the more usual B-lymphocyte form. This situation is analogous to that described previously in chronic lymphocytic leukemia and other lymphoproliferative disorders.





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