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Autoimmune Thyroid Diseases—Graves' and Hashimoto's

JOSIAH BROWN, M.D.; D. H. SOLOMON, M.D., F.A.C.P.; G. N. BEALL, M.D., F.A.C.P.; P. I. TERASAKI, Ph.D.; I. J. CHOPRA, M.D., F.A.C.P.; A. J. VAN HERLE, M.D.; and S.-Y. WU, M.D., Ph.D.
[+] Article, Author, and Disclosure Information

▸Requests for reprints should be addressed to Josiah Brown, M.D.; Division of Endocrinology and Metabolism, UCLA Center for the Health Sciences; Los Angeles, CA 90024.

Los Angeles, California

© 1978 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1978;88(3):379-391. doi:10.7326/0003-4819-88-3-379
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Thyroid-related autoimmune diseases (Graves' thyroid disease, Graves' ophthalmopathy, and Hashimoto's thyroiditis) may occur alone or in any association. The diagnosis of Hashimoto's thyroiditis requires multiple criteria; pathologic changes in the thyroid are not due to antibodies but may result from cytotoxic lymphocytes or a deficiency of suppressive T cells. In Graves' and Hashimoto's diseases the increased prevalence of HLA-B8 may not be significant, but that of HLA-AW30 in Hashimoto's disease is. In 48 first-degree relatives of patients with Graves' disease, thyroid abnormalities were frequent but not correlated with HLA type. Elevated serum thyroglobulin levels in all patients with hyperthyroidism fell to normal after surgical resection or radioiodine therapy. Patients whose illness recurred after antithyroid drug treatment was stopped had higher pretreatment thyroglobulin levels and no fall during treatment; those whose illness remitted had lower initial levels and a significant fall during treatment. Sodium ipodate lowered serum triiodothyronine and thyroxine levels in hyperthyroid patients and may be useful in the treatment of hyperthyroidism.





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