0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Plasma Glucose, Insulin, Glucagon, and Growth Hormone in Kindreds with Maturity-Onset Type of Hyperglycemia in Young People

JOSE BARBOSA, M.D., M.Sc.; ROBERT RAMSAY, M.D.; and FREDERICK C. GOETZ, M.D.
[+] Article and Author Information

Grant support: by General Clinical Research Centers Program (RR-400); The Division of Research Resources, National Institutes of Health; Bush Foundation, St. Paul, Minnesota; and Minnesota Medical Foundation, Minneapolis, Minnesota.

Presented in part at the 35th Annual Meeting of the American Diabetes Association, 3 through 6 June 1975, New York, New York.

▸Requests for reprints should be addressed to Jose Barbosa, M.D.; Box 504 Department of Medicine, University of Minnesota Hospitals; Minneapolis, MN 55455.


Minneapolis, Minnesota


©1978 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1978;88(5):595-601. doi:10.7326/0003-4819-88-5-595
Text Size: A A A

Two kindreds affected by maturity-onset type of hyperglycemia in young people were studied. The postglucose-load hyperglycemia segregated as an autosomal dominant trait; it was always mild, never requiring insulin, and generally seemed to start in the first two decades of life. Glucose, insulin, glucagon, and growth hormone were measured during glucose-tolerance tests in patients, relatives, and control subjects. Most hyperglycemic patients were found to have insulin deficiency. There was no correlation between the age of the patients and insulin secretion. Plasma glucagon and growth hormone were normal. Maturity-onset type of hyperglycemia in young people may be a frequent type of hyperglycemia, and its identification will generally depend on the presence of a strong family history. The recognition of maturity-onset type of hyperglycemia in young people as a specific disease different from juvenile, insulin-dependent diabetes is important, especially to prevent unnecessary use of insulin in hyperglycemic children.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)