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Plasma Glucose, Insulin, Glucagon, and Growth Hormone in Kindreds with Maturity-Onset Type of Hyperglycemia in Young People

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Grant support: by General Clinical Research Centers Program (RR-400); The Division of Research Resources, National Institutes of Health; Bush Foundation, St. Paul, Minnesota; and Minnesota Medical Foundation, Minneapolis, Minnesota.

Presented in part at the 35th Annual Meeting of the American Diabetes Association, 3 through 6 June 1975, New York, New York.

▸Requests for reprints should be addressed to Jose Barbosa, M.D.; Box 504 Department of Medicine, University of Minnesota Hospitals; Minneapolis, MN 55455.

Minneapolis, Minnesota

©1978 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1978;88(5):595-601. doi:10.7326/0003-4819-88-5-595
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Two kindreds affected by maturity-onset type of hyperglycemia in young people were studied. The postglucose-load hyperglycemia segregated as an autosomal dominant trait; it was always mild, never requiring insulin, and generally seemed to start in the first two decades of life. Glucose, insulin, glucagon, and growth hormone were measured during glucose-tolerance tests in patients, relatives, and control subjects. Most hyperglycemic patients were found to have insulin deficiency. There was no correlation between the age of the patients and insulin secretion. Plasma glucagon and growth hormone were normal. Maturity-onset type of hyperglycemia in young people may be a frequent type of hyperglycemia, and its identification will generally depend on the presence of a strong family history. The recognition of maturity-onset type of hyperglycemia in young people as a specific disease different from juvenile, insulin-dependent diabetes is important, especially to prevent unnecessary use of insulin in hyperglycemic children.





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