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Diagnosis and Treatment |

Asymptomatic Hyperuricemia: The Case for Conservative Management

[+] Article, Author, and Disclosure Information

Grant support: from the Robert Wood Johnson Clinical Scholar Program and the Northern California Arthritis Foundation.

▸Requests for reprints should be addressed to Matthew H. Liang, M.D.; Robert B. Brigham Hospital, 125 Parker Hill Ave.; Boston, MA 02120.

Boston, Massachusetts, and Stanford, California

©1978 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1978;88(5):666-670. doi:10.7326/0003-4819-88-5-666
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The management of asymptomatic hyperuricemia is controversial. Reported benefits from treatment include prevention of acute gouty arthritis, chronic tophaceous gout, urolithiasis, or gouty nephropathy. A review of experimental and clinical data suggests that the risks of asymptomatic hyperuricemia are small or unknown and the efficacy of long-term treatment in preventing gout or renal disease is unproved. The costs and risks of prolonged drug administration and practical considerations such as patient compliance mitigate against long-term therapy in asymptomatic persons. We offer some recommendations for an expectant approach to the management of asymptomatic hyperuricemia.





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