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Influenzal Vaccine Response in Systemic Lupus Erythematosus

RICHARD BRODMAN, M.D.; ROBERT GILFILLAN, Ph.D.; DAVID GLASS, M.B., Ch.B., M.R.C.P.; and PETER H. SCHUR, M.D., F.A.C.P.
[+] Article and Author Information

Grant support: in part by U.S. Public Health Service Grants AM11414, AM05577, AI00366, and Contract No. 4512-0179, Massachusetts Department of Public Health, National Influenza Immunization Program. Dr. Brodman is the recipient of U.S. Public Health Service Research Fellowship AM05446.

▸Requests for reprints should be addressed to Peter H. Schur, M.D., F.A.C.P.; 125 Parker Hill Avenue; Boston, MA 02120.


Boston, Massachusetts


© 1978 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1978;88(6):735-740. doi:10.7326/0003-4819-88-6-735
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The response of patients with systemic lupus erythematosus and normal subjects to systemic immunization and boosting with influenza A vaccines was studied. Symptoms after vaccination were somewhat more frequent in the patients than in the normal subjects; however, all symptoms were minor and no major flare of illness occurred. No significant induction or increase of pre-existing autoantibodies among the patients was detected after vaccination. The immunogenecity of the vaccinations, as assessed by antibody titers, was similar in the patient and control groups. No correlation between serologic response to influenzal antigens and HLA was found. Thus, in this group of patients with systemic lupus erythematosus, who were either in remission or had mild-to-moderate disease activity, killed influenzal vaccination caused no apparent worsening of disease activity.

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