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Bone-Marrow Mast Cells in Lymphoproliferative Disorders

DAL YOO, M.D.; LAWRENCE S. LESSIN, M.D.; and WALLACE N. JENSEN, M.D.
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▸Requests for reprints should be addressed to Lawrence S. Lessin, M.D.; Division of Hematology and Oncology, George Washington University Medical Center, 2150 Pennsylvania Ave., Suite 626; Washington D.C. 20037.


Washington, D.C., and Albany, New York


© 1978 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1978;88(6):753-757. doi:10.7326/0003-4819-88-6-753
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Increased bone-marrow mast-cell content and lymphoproliferative disorders have been previously linked. Using a semiquantitative method we examined bone-marrow mast-cell content in 120 marrow specimens from patients with multiple myeloma, chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and reactive lymphocytosis. Results indicated a statistically significant increase of marrow mast-cell content in patients with chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and reactive lymphocytosis when compared with iron-deficient control subjects (p ≤ 0.0005). Patients with multiple myeloma had decreased marrow mast-cell content, clearly separating them from patients with lymphoproliferative disorders and reactive lymphocytosis. Linear regression plot of marrow mast-cell content against percentage of marrow lymphocytes showed a direct relation, indicating that marrow mast-cell density may be related more to the degree of lymphoid proliferation than to the specific lymphoproliferative process. Marrow mast-cell content may therefore be reproducibly determined and used to support the morphologic diagnosis of lymphoproliferative disorders and differentiate them from atypical myelomas.

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