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Mixed Anaplastic Small-Cell and Squamous-Cell Carcinoma of the Lung

HARMAR D. BRERETON, M.D.; MARY M. MATHEWS, M.D.; JOSE COSTA, M.D.; C. HARRY KENT, M.D.; and RALPH E. JOHNSON, M.D.
[+] Article and Author Information

Radiation Oncology and Pathology Branches, National Cancer Institute; Bethesda, Maryland; and Veterans Administration Medical Onocology Branch, National Cancer Institute; Washington, D.C.


© 1978 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1978;88(6):805-806. doi:10.7326/0003-4819-88-6-805
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This excerpt has been provided in the absence of an abstract.

The pleomorphism of lung cancer is well known and the appearance of histologically well and poorly differentiated areas within a tissue specimen, or even the coexistence of multiple discreet histologic subtypes, is not uncommon. The association, however, of small-cell anaplastic and squamous-cell lung cancer has been rarely noted, and we report here a 24% prevalence of this association in an autopsy series.

Fifty consecutive previously untreated patients with biopsy-proven small-cell carcinoma of the lung were studied between November 1974 and May 1975. Each diagnostic biopsy contained only small-cell anaplastic elements. All patients were evaluated with sequential chest radiographs, whole lung

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