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Diagnosis and Treatment |

Vancomycin Revisited

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▸Requests for reprints should be addressed to W. Edmund Farrar, Jr., M.D.; Infectious Diseases-Immunology Division, Medical University of South Carolina, 171 Ashley Ave.; Charleston, SC 29403.

Charleston, South Carolina

© 1978 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1978;88(6):813-818. doi:10.7326/0003-4819-88-6-813
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Vancomycin, virtually discarded after development of antistaphylococcal penicillins, has recently been receiving renewed attention. There are several clinical situations in which it appears to offer advantages over other available antimicrobial agents: infections due to methicillin-resistant staphylococci; bacterial endocarditis in patients allergic to penicillin; staphylococcal enterocolitis; staphylococcal infection in patients undergoing hemodialysis; infections caused by penicillin-resistant diphtheroids; and prophylaxis of bacterial endocarditis in patients with prosthetic valves or penicillin allergy. Its penetration into the cerebrospinal fluid suggests that vancomycin may be useful in treating certain infections of the central nervous system. Although its ototoxic and nephrotoxic potential cannot be ignored, these problems can be minimized by keeping the serum concentration at the proper level.







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