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Mitral-Valve Prolapse Syndrome and Recurrent Ventricular Tachyarrhythmias: A Malignant Variant Refractory to Conventional Drug Therapy

JEANNE Y. WEI, M.D.; BERNADINE H. BULKLEY, M.D.; ALLEN H. SCHAEFFER, M.D.; H. LEON GREENE, M.D.; and PHILIP R. REID, M.D.
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▸Requests for reprints should be addressed to Philip R. Reid, M.D.; Osler 503, The Johns Hopkins Hospital; Baltimore, MD 21205.


Baltimore, Maryland


© 1978 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1978;89(1):6-9. doi:10.7326/0003-4819-89-1-6
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Of 60 patients referred for management of drug-refractory ventricular tachyarrhythmias, 10 (17%) had mitral-valve prolapse. These 10 patients ranged in age from 19 to 70 years (mean, 47 years); seven were women. All 10 had recurrent ventricular tachycardia, while four had a history of ventricular fibrillation. Nine patients were refractory to propranolol in combination with one or more of the standard antiarrhythmic agents. All showed improvement with aprindine therapy. The results show that refractory malignant ventricular arrhythmias may be associated with the mitral-valve prolapse syndrome; patients with mitral-valve prolapse account for a rather high percentage of those patients referred with recurrent drug-refractory ventricular tachyarrhythmias; in patients with unexplained ventricular arrhythmias, mitral-valve prolapse should be considered; and aprindine may be effective for ventricular tachyarrhythmias associated with mitral-valve prolapse.

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