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The Relation of Blood Pressure to Stroke Prognosis

SIMON W. RABKIN, M.D., F.R.C.P.(C); FRANCIS A. L. MATHEWSON, M.D., M.A.C.P.; and ROBERT B. TATE, M.SC.
[+] Article and Author Information

Grant support: in part by a grant from the Department of Health and Welfare; Ottawa, Ontario, Canada.

▸Requests for reprints should be addressed to Simon W. Rabkin, M.D., F.R.C.P.(C); Manitoba Follow-Up Study, Faculty of Medicine; 770 Bannatyne Avenue; Winnipeg, MB, Canada, R3E OW3.


Winnipeg, Manitoba, Canada


© 1978 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1978;89(1):15-20. doi:10.7326/0003-4819-89-1-15
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The relation between blood pressure before stroke and survival after the event, was examined in the Manitoba study cohort of 3983 men. The last recorded blood pressure before the first stroke and the change in blood pressure from a measurement 5 years earlier were used. Increasing magnitude of systolic blood pressure and its 5-year changes were associated with worsening prognosis. The same association was less apparent for diastolic blood pressure and was not found for 5-year change in diastolic pressure. After adjusting for the effect of age at stroke and previous evidence of ischemic heart disease in multivariate analysis, systolic blood pressure and its 5-year change were each significant predictors of short-term (30 days) mortality. Considering all these factors as well as diastolic blood pressure, systolic blood pressure was the best predictor of short-term mortality. Thus, high blood pressure and large positive 5-year change in systolic blood pressure before stroke occurrence are significant predictors of a poor prognosis.

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