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Lymphoblastic-like Leukemic Transformation of Polycythemia Vera

RONALD HOFFMAN, M.D.; SOLOMON ESTREN, M.D.; SAMUEL KOPEL, M.D.; STANLEY M. MARKS, M.D.; and RONALD P. McCAFFREY, M.D.
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Grant support: by the Anna Fuller Fund, New Haven, Connecticut.


Ann Intern Med. 1978;89(1):71. doi:10.7326/0003-4819-89-1-71
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Polycythemia vera terminates in acute leukemia in 0 to 30% of cases, depending on the series cited (1). The nature of this leukemic transformation has not been well characterized but is generally considered to be a variant of acute myeloblastic leukemia. We present here the case of a patient with polycythemia vera who underwent a leukemic transformation. The leukemic blast cells from this patient possessed the morphologic and biochemical features usually associated with blast cells of patients with acute lymphoblastic leukemia.

In 1971, a 77-year-old white man underwent a prostatectomy for benign prostatic hypertrophy. The procedure was complicated by excessive

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