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Hypersplenic Thrombocytopenia Differentiated from Increased Peripheral Destruction by Platelet Volume

SIMON KARPATKIN, M.D.; and MICHAEL L. FREEDMAN, M.D., F.A.C.P.
[+] Article and Author Information

▸Requests for reprints should be addressed to Simon Karpatkin, M.D., 550 First Avenue; New York, NY 10016.


New York, New York


© 1978 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1978;89(2):200-203. doi:10.7326/0003-4819-89-2-200
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Platelet volume distribution was examined in 16 patients with hepatosplenomegaly and platelet counts of 45 000 to 90 000/mm3; 12 patients with autoimmune thrombocytopenia and randomly matched platelet counts; and 20 normal subjects. Five platelet volume variables of increasing platelet size were defined from the averages of 20 normal curves. Patients with hypersplenism had decreased volume values of 78% to 87% (mean, 83%) of the average normal population (P < 0.001). Patients with autoimmune thrombocytopenic purpura had values significantly greater than normal by 124% to 149% (mean, 134%) (P < 0.001). Patients with autoimmune thrombocytopenic purpura, when compared with hypersplenic patients, had significantly greater platelet volume values ranging from 154% to 174% (mean, 161%), P < 0.001. We concluded that patients with hepatosplenomegaly have smaller platelets in their peripheral blood and a platelet volume distribution that can be distinguished easily from patients with autoimmune thrombocytopenic purpura, despite comparable platelet counts.

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