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Interstitial Pneumonia from Mitomycin

ERIC S. ORWOLL, M.D.; PETER J. KIESSLING, M.D.; and JAMES R. PATTERSON, M.D.
[+] Article and Author Information

Dr. Orwoll is Veterans Administration Investigator MRIS #648-6655.

▸ Requests for reprints should be addressed to Eric S. Orwoll, M.D.; 3710 S.W. U.S. Veterans Hospital Road; Portland, OR 97201.


Portland, Oregon


©1978 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1978;89(3):352-355. doi:10.7326/0003-4819-89-3-352
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Pulmonary disease has been associated with several chemotherapeutic agents but has not been reported in patients receiving the alkylating agent mitomycin (Mutamycin®). We describe here the cases of three patients who developed interstitial pneumonia while receiving mitomycin therapy. Their clinical features included dyspnea, cough, and occasionally fever; reticular infiltrates were seen on chest roentgenogram. Histologically, diffuse alveolar septal edema, mononuclear-cell interstitial infiltrates, hypertrophy of alveolar lining cells, and alveolar septal collagen deposition were characteristic. Treatment with corticosteroids was associated with a rapid therapeutic response in all three patients.

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