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Thrombotic Thrombocytopenic Purpura Fails to Respond to Fresh Frozen Plasma Infusion

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University of Massachusetts Medical Center; Worcester, Massachusetts

Ann Intern Med. 1978;89(5_Part_1):647-648. doi:10.7326/0003-4819-89-5-647
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Recent reports have emphasized the therapeutic success of exchange transfusion (1, 2), plasmapheresis (3), and plasma infusion (4) in the treatment of thrombotic thrombocytopenic purpura. We report a case of this disease showing the effectiveness of exchange transfusion and plasmapheresis and the failure of fresh frozen plasma infusion.

A 28-year-old white woman presented with severe headaches and fatigue. Physical examination showed a pale, lethargic woman with scattered petechiae. There was no lymphadenopathy or hepatosplenomegaly and the results of the remainder of the examination were unremarkable. Laboratory data showed an hematocrit of 23%, reticulocyte count of 13%, microangiopathic erythrocyte structure, and


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