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VII. Problems That Need Clinical Investigation |

The Need for Controlled Clinical Studies in Antimicrobial Therapy

MERLE A. SANDE, M.D., F.A.C.P.
[+] Article and Author Information

▸Requests for reprints should be addressed to Merle A. Sande, M.D.; Department of Internal Medicine, Division of Infectious Diseases, University of Virginia School of Medicine; Charlottesville, VA 22901.


Charlottesville, Virginia


© 1978 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1978;89(5_Part_2):857-859. doi:10.7326/0003-4819-89-5-857
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In recent years in-vitro and in-vivo studies have greatly advanced our understanding of the action of antimicrobial agents and have opened new potential avenues for treatment of infectious diseases. Unfortunately, little interest or financial support has been available to test these observations in rigid, controlled clinical studies. New regimens have thus been used without proof of increased efficacy or reduced toxicity over old regimens. Carefully controlled clinical trials are particularly needed to evaluate the efficacy, toxicity, and cost of newly developed regimens in the therapy of chronic bacterial and fungal infections.

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