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Rapid Hemostasis with Topical Thrombin After Hemodialysis

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University of California Irvine Medical Center; Orange, California

Ann Intern Med. 1978;89(6):936-937. doi:10.7326/0003-4819-89-6-936
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Internal Arteriovenous (AV) fistulae have gradually replaced external shunts for maintenance dialysis in recent years. The internal AV fistulae are generally superior to the external shunts. One of their few undesirable side effects, however, is prolonged bleeding from the puncture sites at the end of dialysis. This usually requires lengthy compression of bleeding sites, which is not only time consuming but also damaging to the vascular access.

During the past 4 months I have conducted several double-blind studies to investigate the efficacy of topical thrombin in the control of bleeding from the puncture sites in dialysis patients. I present


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