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Diagnosis and Treatment |

Drugs Five Years Later: Calusterone

RICHARD A. BRODKIN, M.D.; and M. ROBERT COOPER, M.D.
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▸Requests for reprints should be addressed to Richard A. Brodkin, MD.; Department of Medicine/Hematology, Bowman Gray School of Medicine, 300 S. Hawthorne Rd.; Winston-Salem, NC 27103.


Winston-Salem, North Carolina


©1978 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1978;89(6):945-948. doi:10.7326/0003-4819-89-6-945
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Androgens are effective therapeutic agents in postmenopausal women with metastatic breast cancer. Early studies with testosterone propionate showed objective regression rates of slightly more than 20%. Subsequent work with synthetic androgens has failed to show a significant reduction in toxicity or an increase in therapeutic efficacy over testosterone propionate. Calusterone (7β,17α-dimethyltestosterone), in early clinical trials, showed both of these qualities and was believed by some to be the "ideal androgen." As with many new drugs, subsequent work failed to confirm these early findings, and most of the later data gathered on calusterone are inconsistent. We conclude from our knowledge at present that calusterone offers no real advantages or disadvantages over other androgens in the treatment of breast cancer.

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