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Converting Enzyme Inhibition in Hypertensive Emergencies

CHARLES P. TIFFT, M.D.; HARALAMBOS GAVRAS, M.D.; GLENN R. KERSHAW, M.D.; IRENE GAVRAS, M.D.; HANS R. BRUNNER, M.D.; CHANG-SENG LIANG, M.D.; and ARAM V. CHOBANIAN, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Haralambos Gavras, M.D.; Boston University Medical Center School of Medicine; 80 East Concord Street; Boston, MA 02118.


Boston, Massachusetts


© 1979 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1979;90(1):43-47. doi:10.7326/0003-4819-90-1-43
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The diagnostic and therapeutic value of the angiotens-inconverting enzyme inhibitor teprotide (SQ 20881) was assessed in 18 patients with hypertensive emergencies. Mean blood pressure fell 31 ± 18 mm Hg in the 10 subjects who responded to 1 mg/kg body weight administered intravenously, whereas it fell 5 ± 3 mm Hg in the eight nonresponders. In patients who had received no previous drug treatment, log baseline plasma renin activity and change in mean blood pressure after SQ 20881 correlated significantly (r = 0.651, P < 0.05). After acute therapy with SQ 20881, the patients who had a satisfactory response to the drug were treated with propranolol and a relatively normal sodium intake (88 meq/day). Nonresponders were treated with diuretics and sodium restriction (10 meq/day), and intermediate responders were given combination therapy. Mean blood pressure responded favorably within 24 h to the chosen regimen for each group from 152 ± 47 to 102 ± 31 mm Hg. SQ 20881 allows prompt evaluation of the role of renin in hypertensive emergencies and permits early choice of appropriate therapy based on the prevailing mechanism.

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