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Some Progress with Systemic Sclerosis

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Division of Rheumatology, The Jefferson Medical College of Thomas Jefferson University; Philadelphia, Pennsylvania

Ann Intern Med. 1979;90(1):117-118. doi:10.7326/0003-4819-90-1-117
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The treatment of systemic sclerosis has been ineffectual despite past enthusiasm for some drugs, notably corticosteroids, dimethyl sulfoxide, epsilon aminocaproic acid, potassium para-amino benzoic acid, and edetate disodium. Recent reports have brought promise of advances in management. The results of renal transplantation have been better than expected (1-3). D-Pencillamine may be effective in early disease (4-6), and the previously inevitable fatal outcome for the patient with severe renal failure and hypertension seems to be reversible with antihypertensive therapy and chronic renal dialysis (7-9).

Diagnosis of scleroderma is rarely difficult in its advanced form. The clinician readily recognizes typical leathery and


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