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Beneficial Effects of Hepatitis in Patients with Acute Myelogenous Leukemia

[+] Article, Author, and Disclosure Information

This study was supported by a grant from the National Heart, Lung, and Blood Institute (1RO1HL20856). Dr. Barton is the recipient of a Research Fellowship award from the National Cancer Institute (1F32 CA05977).

▸Requests for reprints should be addressed to Marcel E. Conrad, M.D.; Division of Hematology/Oncology, School of Medicine, University of Alabama; Birmingham, AL 35294.

Birmingham, Alabama

©1979 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1979;90(2):188-190. doi:10.7326/0003-4819-90-2-188
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Of 50 consecutive patients admitted with acute myelogenous leukemia, 30 developed complete remissions on antileukemic therapy. Nineteen of the 30 repeatedly had elevated serum glutamic oxalacetic transaminase (SGOT) concentrations 3 to 14 weeks after the start of therapy. Patients with SGOT elevations had a significantly greater chance of remission and a longer survival (76 ± 11 weeks) than those with normal SGOT levels (39 ± 5 weeks), suggesting that hepatitis may have a beneficial effect in acute myelogenous leukemia. The hepatitis was mild in all patients. Review of patients at this institution alive 2 years after the diagnosis of acute myelogenous leukemia showed that they repeatedly had elevated SGOT levels. We believe that most had non-A, non-B post-transfusion hepatitis, which may have a beneficial effect on the leukemia or serve as an indicator of patients who have greater immunocompetence and thus a better prognosis.





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