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Angiotensin-I-Converting Enzyme and Gallium Scan in Noninvasive Evaluation of Sarcoidosis

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▸Requests for reprints should be addressed to Aileen Nosal, M.D.; Outpatient Chest Services, Harbor General Hospital, Chest Disease Referral Center; 1000 West Carson Street, Building C-4; Torrance, CA 90509.

Torrance, California

© 1979 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1979;90(3):328-331. doi:10.7326/0003-4819-90-3-328
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Angiotensin-converting enzyme assays and gallium-scan results were obtained from 27 patients with biopsy-proven, clinically active sarcoidosis. Twenty-three of these patients had elevated converting enzyme levels, and 22 had positive gallium-scan results. Three of four patients with normal or borderline-elevated levels of angiotensin-converting enzyme also had positive gallium-scan results. Of 156 nonsarcoid patients (pulmonary and other diseases), 27 were found to have elevated serum converting enzyme levels, and 25 of these had negative gallium-scan results. These results indicate that the combination of an assay of angiotensin-converting enzyme and gallium scan increases diagnostic specificity from 83% to 99% without sacrificing sensitivity. We conclude that the concurrent use of angiotensin-converting enzyme assay and gallium scan is of value in the diagnosis of sarcoidosis.





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