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Renal Excretion of 99mTc-Diphosphonate in Osteomalacia

J. D. MACFARLANE, B.M.; M. R. A. KHAIRI, M.D.; M. RICCIARDONE, B.S.; H. N. WELLMAN, M.D.; and C. C. JOHNSTON Jr., M.D.
[+] Article and Author Information

This study was supported in part by a grant from Procter and Gamble, Cincinnati, Ohio.


Indiana University School of Medicine; Indianapolis, Indiana


Ann Intern Med. 1979;90(3):350-351. doi:10.7326/0003-4819-90-3-350
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Interest in bone scanning in metabolic bone disease has led to the identification of pseudofractures in osteomalacia (1), the assessment of the severity of renal osteodystrophy (2), and the suggestion that calculation of bone to soft-tissue ratios may help distinguish patients with bone disease from normal control persons (3). These techniques are relatively crude and do not necessarily indicate the real skeletal accretion or whole body retention of the radionuclide. During a study of sequential bone to soft-tissue ratios in patients with various bone diseases, we estimated the renal excretion of 99mTc-ethane-1-hydroxy-1, 1-diphosphonate (99mTc-EHDP). We report here our findings from

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