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Solid Tumors in Multiple Myeloma

[+] Article, Author, and Disclosure Information

Grant support: CA-03195 and CA-05831 from the National Cancer Institute, National Institutes of Health; Bethesda, Maryland.

▸Requests for reprints should be addressed to Raymond Alexanian, M.D.; Department of Medicine, M.D. Anderson Hospital and Tumor Institute; 6723 Bertner Avenue; Houston, TX 77030.

Houston, Texas

Ann Intern Med. 1979;90(5):780-782. doi:10.7326/0003-4819-90-5-780
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The frequency of solid tumors was evaluated in 628 consecutive patients with multiple myeloma who had been treated with various melphalan-prednisone combinations. Among those patients who lived at least 2 months, the incidence and diversity of second tumors were similar to those in normal persons of the same age and duration at risk. The diagnosis was usually made within 2 years after the start of chemotherapy for the myeloma. Long-term melphalan therapy did not seem to contribute to the pathogenesis of second solid tumors in patients with multiple myeloma.





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