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Neisseria meningitidis and Neisseria gonorrhoeae Bacteremia Associated with C6, C7, or C8 Deficiency

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This study was supported by grants AI 13927, AI 15642, and AI 15036 from the National Institute of Allergy and Infectious Diseases and DE 03738-05 from the National Institute for Dental Research. Dr. Snyderman is an investigator of the Howard Hughes Medical Institute.

▸Requests for reprints should be addressed to Bruce H. Petersen, Ph.D.; Lilly Laboratory for Clinical Research, Wishard Memorial Hospital, 1001 West 10th Street; Indianapolis, IN 46202.

Indianapolis, Indiana; Chapel Hill and Durham, North Carolina; and San Francisco, California

© 1979 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1979;90(6):917-920. doi:10.7326/0003-4819-90-6-917
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We summarize data from 24 previously described or newly diagnosed cases of homozygous deficiency of the sixth, seventh, or eighth components of complement. Thirteen of 24 patients had at least one episode, and usually two or more episodes of Neisseria meningitidis or Neisseria gonorrhoeae bacteremia, or both. Deficiency of C6, C7, or C8 is a meaningful risk factor for repeated neisserial bacteremia; conversely, hemolytic complement studies are indicated in patients who develop recurrent neisserial infections. When a person with C6, C7, or C8 deficiency is identified, family members should also be studied.





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