The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Serum Triiodothyronine and Other Clinical and Laboratory Indices of Alcoholic Liver Disease

P. G. WALFISH, M.D.; H. ORREGO, M.D.; Y. ISRAEL, Ph.D.; J. BLAKE, M.Sc.; and H. KALANT, M.D., Ph.D.
[+] Article, Author, and Disclosure Information

This work was supported by a grant from the Addiction Research Foundation of Ontario.

This paper was presented in part at the 9th Annual Meeting of the European Thyroid Association, Berlin, West Germany, 4-8 September 1978, and published as an abstract in Ann Endocrinol (Paris). 1978; T-39 (suppl):13A.

▸Requests for reprints should be addressed to P. G. Walfish, M.D.; Mount Sinai Hospital, Suite 639-640, 600 University Avenue; Toronto, ON M5G 1X5, Canada.

Toronto, Canada

© 1979 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1979;91(1):13-16. doi:10.7326/0003-4819-91-1-13
Text Size: A A A

Admission serum triiodothyronine (T3) values in 124 patients hospitalized for alcoholic liver disease were correlated with clinical and laboratory indices of liver function and commonly used determinants of thyroid function. Patients with low admission serum T3 levels had significant alterations in serum albumin, bilirubin, prothrombin time, and alkaline phosphatase associated with clinical signs of portal hypertension and collateral circulation, with little difference in serum glutamic-oxaloacetic transaminase, serum gamma glutamyl transpeptidase, or serum ornithine carbamyl transferase. This group also had a significant decrease in free T3 index despite an increase in T3 uptake; the slight reduction in total thyroxine (T4) was associated with an increase in free T4 index and no change in serum thyrotropin (TSH). For patients with alcoholic liver disease, low admission serum T3 and free T3 index values when accompanied by normal serum T4, free T4 index, and TSH levels appear to be indicative of severe liver dysfunction and increased mortality risk.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.