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Primary Familial Bilateral Carpal Tunnel Syndrome

[+] Article, Author, and Disclosure Information

This work was supported in part by a training grant in arthritis and rheumatic diseases from the National Institutes of Health (NIH-AM05058); the Dade County Division of the Arthritis Foundation; and the Applebaum, Greenberg and Oritt Funds.

▸Requests for reprints should be addressed to Norman L. Gottlieb, M.D.; Division of Rheumatology 4-10, P.O. Box 016960; Miami, FL 33155.

Springfield, Massachusetts; and Miami, Florida

© 1979 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1979;91(1):37-40. doi:10.7326/0003-4819-91-1-37
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We identified bilateral carpal tunnel syndrome in 19 of 43 living persons of a nonconsanguineous family. No single common etiologic feature was seen. Sixty-three percent of the afflicted kindred had symptomatic digital flexor tenosynovitis. Noninflammatory thickening of the flexor retinaculum or tendon sheaths, or both, was the commonest surgical finding. The 44% prevalence, early age of onset, and equal sex ratio differ from idiopathic carpal tunnel syndrome. Family pedigree suggests an inheritable disorder transmitted by an autosomal dominant gene with a high degree of penetrance.





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