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Prolactin-Secreting Pituitary Adenomas in Multiple Endocrine Adenomatosis, Type I

PETERMAN R. PROSSER, M.D.; JOHN H. KARAM, M.D.; JEANNETTE J. TOWNSEND, M.D.; and PETER H. FORSHAM, M.D.
[+] Article and Author Information

Grant support: U.S. Public Health Service Grant AM-12763(08); the Levy J. and Mary Skaggs Foundation of Oakland, California; and the Susan Greenwall Foundation of New York, New York. Clinical studies were carried out in the General Clinical Research Center, University of California, San Francisco, with funds provided by the U.S. Public Health Service Division of Research Resources, RR-79.

▸Requests for reprints should be addressed to John H. Karam, M.D. Metabolic Research Unit, 1143 HSW, University of California, San Francisco; San Francisco, CA 94143.


San Francisco, California


© 1979 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1979;91(1):41-44. doi:10.7326/0003-4819-91-1-41
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In three unrelated families, four patients with multiple endocrine adenomatosis, type I, had confirmed or highly probable prolactin-secreting pituitary adenomas. In one patient, selective transsphenoidal tumor resection resulted in normal prolactin levels and resumption of menses. Heretofore, the majority of pituitary tumors in such patients had been thought to be nonsecreting chromophobe adenomas, but recent studies have shown that, in sporadic cases, as many as three fourths of "nonsecreting" pituitary tumors in fact secrete prolactin. Thus, based on our experience and reports of others, we believe that prolactin-secreting tumors may be common in patients with pituitary tumors as part of the syndrome of multiple endocrine adenomatosis, type I, and we recommend that serum prolactin be measured when evaluating these patients and their families.

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