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Pheochromocytoma Associated with Hypercalcemia and Ectopic Secretion of Calcitonin

[+] Article, Author, and Disclosure Information

This work was supported in part by grants from the National Institutes of Health (AM-21101 and AM-19607) and the Mayo Foundation.

▸Requests for reprints should be addressed to Hunter Heath III, M.D.; Mayo Clinic, 4-407 Alfred Building; Rochester, MN 55901.

Rochester, Minnesota

© 1979 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1979;91(2):208-210. doi:10.7326/0003-4819-91-2-208
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A 17-year-old woman manifested fever, abdominal pain, headache, and hypertension caused by a solitary, benign pheochromocytoma. She also had hypercalcemia and elevated plasma immunoreactive calcitonin levels. After removal of the pheochromocytoma, calcium and calcitonin levels returned to normal. Studies of peripheral and tumor venous blood showed no excess or ectopic parathyroid hormone secretion, but the tumor contained and secreted calcitonin. Sporadic pheochromocytoma may secrete calcitonin and cause hypercalcemia by non-parathyroid hormone-mediated mechanisms. The potential is clearly present for confusion with multiple endocrine neoplasia, type 2 (medullary thyroid carcinoma, pheochromocytoma, and primary hyperparathyroidism).





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