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Hairy-Cell Leukemia Presenting as Aplastic Anemia

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St. Bartholomew's Hospital; London, England

© 1979 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1979;91(2):228. doi:10.7326/0003-4819-91-2-228
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Hairy-cell leukemia typically presents with a reduction in normal peripheral blood cells and variable numbers of circulating mononuclear cells with prominent cytoplasmic projections. The blood changes are usually associated with effacement of bone-marrow architecture by a diffuse mononuclear cell infiltrate and a characteristic pattern of increased delicate fibrosis seen on marrow

Figure 1. Marrow biopsy in hairy-cell leukemia presenting as aplastic anemia. (Haematoxylin and eosin; original magnification, X 150.) Horizontal bar = 1 mm.

biopsy (1-3). During the past 3 years, four patients with hairy-cell leukemia have been referred to our departments with peripheral blood cytopenias but bone-marrow hypoplasia of such degree that they were originally diagnosed as having aplastic anemia. This presentation has not been described previously.

Three patients presented with anemia


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