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Direct Binding Studies of Adrenergic Receptors: Biochemical, Physiologic, and Clinical Implications

ROBERT J. LEFKOWITZ, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Robert J. Lefkowitz, M.D.; P.O. Box 3325, Duke University Medical Center; Durham, NC 27710.


Durham, North Carolina A New York University Honors Program Lecture


© 1979 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1979;91(3):450-458. doi:10.7326/0003-4819-91-3-450
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Recently developed radioligand binding techniques permit direct investigation of the alpha- and beta-adrenergic receptors for catecholamines in a wide variety of tissues. These techniques allow the receptors to be quantitated, characterized, and studied under varying conditions of physiologic and pathophysiologic interest. They are providing fresh insights into the mechanisms by which endogenous catecholamines and other hormones regulate the properties of the adrenergic receptors and, in turn, control tissue sensitivity to catecholamine action.

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