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Recurrent Urinary Tract Infections in Men: Characteristics and Response to Therapy

JAMES W. SMITH, M.D.; STEPHEN R. JONES, M.D.; WILLIAM P. REED, M.D.; ALAN D. TICE, M.D.; ROBERT H. DEUPREE, Ph.D.; and BERTIL KAIJSER, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to James W. Smith, M.D.; Infectious Disease Section (111D), Veterans Administration Medical Center, 4500 South Lancaster Road; Dallas, TX 75216.


Dallas, Texas; Portland, Oregon; Albuquerque, New Mexico; Providence, Rhode Island; West Haven, Connecticut; and Goteborg,Sweden


Ann Intern Med. 1979;91(4):544-548. doi:10.7326/0003-4819-91-4-544
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All men with recurrent urinary tract infections entered into a study had a positive antibody-coated bacteria test, and 52% had evidence for prostate infection. Escherichia coli infection was present in 74% and urinary tract symptoms in 57% of those randomized. Thirty-eight patients were randomized in a double-blind clinical trial to receive either 10 d of treatment with trimethoprim/sulfamethoxazole or a 12-week course of the drug. The cure rate in patients receiving 12 weeks of therapy (nine of 15) was higher than that in patients receiving a single 10-d course (three of 15); difference was marginally significant (P = 0.06). Recurrences were usually with the same organism, and most (78%) occurred within 4 weeks of discontinuing therapy. This study indicates that a standard 10-d course of therapy usually fails to cure men with recurrent urinary tract infections with a positive antibody-coated bacteria test.

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