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Renal Amyloidosis and Subcutaneous Drug Abuse

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▸Requests for reprints should be addressed to Zeev Sharon, M.D.; Rush-Presbyterian-St. Luke's Hospital, 1753 West Congress Parkway; Chicago, IL 60612.

Chicago, Illinois

© 1979 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1979;91(4):565-567. doi:10.7326/0003-4819-91-4-565
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Two drug addicts who practiced subcutaneous injection of crushed tripelennamine and pentazocine tablets, a practice known as "skin-popping," developed nephrotic syndrome and demonstrated amyloidosis on renal biopsy. These patients had chronic inflammation of the skin in the form of abscesses and ulcerations. Although both patients were long-standing drug abusers, they had practiced intradermal drug administration for only 3 years. The occurrence of amyloidosis in these patients appears to relate to their particular drug habit and must be considered in the differential diagnosis of proteinuria in this patient population.





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