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Infective Endocarditis Caused by Rothia dentocariosa

JEAN PAPE, M.D.; CAROL SINGER, M.D.; TIMOTHY E. KIEHN, Ph.D.; BURTON J. LEE, M.D.; and DONALD ARMSTRONG, M.D.
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Infectious Disease Division, Department of Medicine, New York Hospital, and Cornell University Medical College; New York, New YorkInfectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer CenterNew York, New York


Ann Intern Med. 1979;91(5):746-747. doi:10.7326/0003-4819-91-5-746
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The genus Rothia was created by Georg and Brown (1) in 1967 to include members of the family Actinomycetaceae that resemble Nocardia and Actinomyces morphologically but differ significantly in their physiology and cell wall constituents. The pathogenicity of Rothia dentocariosa, the prototype organism, was first demonstrated experimentally in mice by Roth and Flanagan (2) in 1969. Although the occurrence of R. dentocariosa in the oral cavity is well established, it has rarely been recognized as a human pathogen. The first reported human infection due to R. dentocariosa was described by Scharfen (3) in 1975 in the case of a periappendiceal

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