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5q- Myelodysplasia Terminating in Acute Leukemia

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Veterans Administration Medical Center and The Medical College of Wisconsin; Wood (Milwaukee), Wisconsin

Ann Intern Med. 1979;91(5):748-749. doi:10.7326/0003-4819-91-5-748
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Recently a number of reports (1-7) have described a distinctive type of refractory anemia with an abnormal number 5 chromosome in the bone marrow. We present here a case describing the second instance of the 5q- syndrome terminating in acute myeloblastic leukemia.

An 83-year-old retired bricklayer was admitted in September 1975 with symptoms and signs of acute appendicitis, pallor, a left carotid bruit, and a 6-month history of macrocytic anemia unresponsive to iron, folic acid, or vitamin B12. After recovery from an appendectomy, the patient had a leukocyte count of 3100/µL with 70% neutrophils, 26% lymphocytes, 2% eosinophils, and 2%


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