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Cytomegalovirus Vaccine in Renal Transplants

ROBERT F. BETTS, M.D.
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Infectious Diseases Unit, University of Rochester School of Medicine; Rochester, New York


Ann Intern Med. 1979;91(5):780-782. doi:10.7326/0003-4819-91-5-780
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The understanding of the role of cytomegalovirus (CMV) in disease developing after renal transplantation has increased steadily since the initial realization that CMV infection commonly follows transplantation (1). With the recognition that patients acquired primary infection from virus transplanted with the allograft (2, 3) possible methods to prevent allograft-derived infection have been suggested (4, 5). Because morbidity due to cytomegalovirus is less frequent in persons who were antibody-positive before transplantation than in those developing primary infection (6, 7), it seemed logical to test whether vaccine-induced immunity would reduce CMV-associated morbidity. The study reported in this issue by Glazer and colleagues

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