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▸Requests for reprints should be addressed to Thomas G. Kantor, M.D.; New York University Medical Center, 550 First Avenue; New York, NY 10016.

New York, New York

©1979 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1979;91(6):877-882. doi:10.7326/0003-4819-91-6-877
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Ibuprofen was introduced in England in 1967 and in the United States in 1974 as an anti-inflammatory drug in humans. It has weak but definite anit-inflammatory properties similar to those of aspirin, milligram for milligram, but with considerably less adverse effect on the stomach. Ibuprofen is chemically related to fenoprofen and naproxen, but lack of effect for any one in this chemical class of propionic-acid derivatives does not necessarily mean lack of effect for any other in an individual patient. The drug has analgesic properties, probably related to its anti-inflammatory effect. It inhibits prostaglandin synthesis and has no effect on the adrenopituitary axis, making it a nonsteroidal agent. Ibuprofen has been shown to be efffective in rheumatoid arthritis and osteoarthritis and is probably effective in ankylosing spondylitis, gout, and Bartter's syndrome.







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