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Estimation of Skeletal Involvement in Primary Hyperparathyroidism: Use of 24-Hour Whole-Body Retention of Technetium-99m Diphosphonate

IGNAC FOGELMAN, M.B., Ch.B; RODNEY G. BESSENT, M.A., D.Phil.; GRAHAM BEASTALL, Ph.D.; and IAIN T. BOYLE, M.B., Ch.B.
[+] Article and Author Information

▸Requests for reprints should be addressed to Ignac Fogelman, M.B.; Department of Nuclear Medicine, Royal Infirmary; Glasgow G4 OSF, Scotland.


Glasgow, Scotland


©1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;92(1):65-67. doi:10.7326/0003-4819-92-1-65
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The 24-h whole-body retention of technetium-99m diphosphonate was elevated in 16 patients with primary hyperparathyroidism (mean whole body retention, 50.6%, compared to controls, 19.4%), with each result out of the control range. There was a rank correlation between whole-body retention and plasma parathyroid hormone (r = 0.86, P < 0.001) but the correlation with serum alkaline phosphatase and calcium values was less significant (r = 0.58, P < 0.05 in each case). Repeat studies of whole body retention performed in five patients before and after parathyroidectomy showed a fall to normal or near normal values. Measurement of 24-h whole-body retention of diphosphonate is a simple, sensitive test to aid in the diagnosis and evaluation of patients with primary hyperparathyroidism. The test could be used as a screening procedure in patients with recurrent renal stones, for example, or to assess the extent of skeletal involvement in patients with an established diagnosis.

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