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Reversible Rapidly Progressive Renal Failure with Nephrotic Syndrome Due to Fenoprofen Calcium

GREGORY A. CURT, M.D.; ANTOINE KALDANY, M.D.; LOYD G. WHITLEY, M.D.; ANN W. CROSSON, M.D.; ARTURO ROLLA, M.D.; MANUEL J. MERINO, M.D.; and JOHN A. D'ELIA, M.D.
[+] Article and Author Information

Grant support: AM-09748 and AM-20530, U.S. Public Health Service.


Joslin Diabetes Foundation, New England Deaconess Hospital, and Harvard Medical School; Boston, Massachusetts


Ann Intern Med. 1980;92(1):72-73. doi:10.7326/0003-4819-92-1-72
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Nonsteroidal antiinflammatory drugs have been reported to cause reversible acute renal failure (1-4). Unlike the so-called phenacetin-induced analgesic nephropathy (5), the nephrotoxicity of nonsteroidal antiinflammatory drugs may be secondary to their prostaglandin inhibitory effect (4). We report a case of acute renal failure with nephrotic syndrome due to a hypersensitivity reaction to fenoprofen calcium (Nalfon, Dista Products Company, Indianapolis, Indiana).

A 50-year-old white woman with no history of renal or collagen-vascular disease was admitted on 5 May 1979 for treatment of morbid obesity. She had a history of severe osteoarthritis, sciatica, and surgical release of a left carpal tunnel. She

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