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Thrombosis in Patients with the Lupus Anticoagulant

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Grant support: PHSCA-19087, National Cancer Institute; and program project grant HL 18576-03, National Heart, Lung, and Blood Institute.

▸Requests for reprints should be addressed to Samuel I. Rapaport, M.D.; 225 W. Dickinson Street H 811 K, University Hospital, San Diego, CA 92103

San Diego, California

© 1980 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1980;92(2_Part_1):156-159. doi:10.7326/0003-4819-92-2-156
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A retrospective study was carried out to determine the frequency of thrombosis in patients with the lupus anticoagulant. Thirty-five patients fulfilled laboratory criteria for the diagnosis of the lupus anticoagulant. Eight of these patients had evidence of clinically significant thrombosis while their plasma showed a prolonged partial thromboplastin time due to the anticoagulant. Four of the patients with thrombosis had concurrent autoimmune disease and three other patients were receiving phenothiazine medication. Moderate thrombocytopenia was noted in four patients with thrombosis. None of the patients with the lupus anticoagulant bled abnormally. This study suggests that patients with the lupus anticoagulant may be at increased risk of thrombosis.





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