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Histoplasma Meningitis: Diagnostic Value of Cerebrospinal Fluid Serology

JOSEPH F. PLOUFFE, M.D.; and ROBERT J. FASS, M.D.
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▸Requests for reprints should be addressed to Joseph F. Plouffe, M.D.; N-1135, Department of Medicine, Ohio State University; 410 10th Avenue; Columbus, OH 43210.


Columbus, Ohio


© 1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;92(2_Part_1):189-191. doi:10.7326/0003-4819-92-2-189
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Two patients with culture-negative chronic meningitis were diagnosed as having Histoplasma capsulatum meningitis based on serial serologic studies; both had antibody in the cerebrospinal fluid as well as the serum. The patients were treated successfully with amphotericin B and had favorable clinical responses. Three control patients with active histoplasmosis and positive serum serologic tests, but without meningeal involvement, did not have antibody in the cerebrospinal fluid. Patients with chronic meningitis of obscure cause should have serial serum and cerebrospinal fluid antibody studies for H. capsulatum.

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