The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Cimetidine as an Immunomodulator: Chronic Mucocutaneous Candidiasis as a Model

[+] Article, Author, and Disclosure Information

Grant support: in part by Public Health Service Research Grant RP-46 from the General Clinical Research Centers Branch of Division of Research Sources and a grant from the Medical Research Service of the Veterans Administration Service.

▸Requests for reprints should be addressed to W. Mitchell Sams, Jr., M.D.; Department of Dermatology, The University of North Carolina School of Medicine; Chapel Hill, NC 27514.

Chapel Hill and Durham, North Carolina

© 1980 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1980;92(2_Part_1):192-195. doi:10.7326/0003-4819-92-2-192
Text Size: A A A

Four adult patients with chronic mucocutaneous candidiasis were studied to establish a possible role for cimetidine as an immunomodulator. These patients had negative baseline in-vivo and in-vitro cell-mediated immune response to candida antigen as measured by intradermal skin tests, lymphocyte transformation, and leukocyte migration inhibitory factor production to candida antigen. Patients were given a 4-week course of cimetidine, 300 mg by mouth, four times daily. Subsequently four of four patients developed strong (> 15 mm) intradermal skin test reactions, and two of four patients produced leukocyte migration inhibitory factor to candida antigen. Skin tests and leukocyte migration inhibitory factor production reverted to baseline negative values when repeated 4 weeks after discontinuation of therapy. After 4 additional weeks on cimetidine, four of four patients showed strong positive skin tests and leukocyte migration inhibitory factor production to candida antigen. Lymphocyte transformation was not affected by therapy.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.