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Diverticular Disease in Patients with Chronic Renal Failure Due to Polycystic Kidney Disease

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Grant support: in part by grants AM-08876 and AM-07126, National Institutes of Health.

Presented in part at the Annual Meeting of the American Gastroenterological Association, May 1979, in New Orleans, Louisiana.

▸Requests for reprints should be addressed to Gary R. Zuckerman, D.O.; Division of Gastroenterology, Washington University School of Medicine, 660 S. Euclid Avenue; St. Louis, MO 63110.

St. Louis, Missouri

© 1980 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1980;92(2_Part_1):202-204. doi:10.7326/0003-4819-92-2-202
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Twelve patients with chronic renal failure and polycystic kidney disease represent 8% of the 151 hemodialysis patients followed up at the Chromalloy American Kidney Center, Washington University School of Medicine. Ten (83%) of these patients have diverticulosis, and four of these patients developed gross colonic perforation secondary to diverticulitis. Barium enemas on 31 chronic renal failure patients without polycystic kidney disease revealed diverticulosis in 10 (32%). None had diverticulitis. Barium enemas in 120 age-matched non-renal failure control patients revealed diverticulosis in 45 (38%). None had diverticulitis. These findings suggest that patients with chronic renal failure due to polycystic kidney disease have a high incidence of diverticulosis and diverticulitis, that diverticulosis occurs in patients with chronic renal failure without polycystic kidney disease at a rate similar to that in the general population, and that diverticulitis should be an initial consideration in the differential diagnosis of abdominal pain in patients with polycystic kidney disease.





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