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Ibuprofen-Related Meningitis in Mixed Connective Tissue Disease

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UCLA Center for the Health Sciences; Los Angeles, California

Ann Intern Med. 1980;92(2_Part_1):206-207. doi:10.7326/0003-4819-92-2-206
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Ibuprofen-related meningitis has been seen infrequently in patients with systemic lupus erythematosus (1-3) but apparently has not been reported in association with mixed connective tissue disease.

A 21-year-old Mexican-American woman developed Raynaud's phenomenon and polyarthritis in February 1979. With salicylates her symptoms were controlled for 6 months until severe arthralgias and myalgias returned. Ibuprofen was prescribed and brought her some relief. A pharyngitis developed and was treated with penicillin. Ibuprofen was withdrawn. Two weeks later, while off all medications, she had a recurrence of arthritis and Ibuprofen was again prescribed. She took a single 400-mg tablet and within 3 hours


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