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Sjögren's Syndrome (Sicca Syndrome): Current Issues

HARALAMPOS M. MOUTSOPOULOS, M.D.; THOMAS M. CHUSED, M.D.; DEAN L. MANN, M.D.; JOHN H. KLIPPEL, M.D.; ANTHONY S. FAUCI, M.D.; MICHAEL M. FRANK, M.D.; THOMAS J. LAWLEY, M.D.; and MAX I. HAMBURGER, M.D.
[+] Article and Author Information

Dr. Moutsopoulos is currently Professor of Medicine at the School of Medicine, University of Ioannina, Ioannina, Greece.

öRequests for reprints should be addressed to Haralampos M. Moutsopoulos, M.D.; Room 2B10, Building 10, National Institutes of Health; Bethesda, MD 20205.


Bethesda, Maryland


Ann Intern Med. 1980;92(2_Part_1):212-226. doi:10.7326/0003-4819-92-2-212
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This paper outlines the clinical, serologic, and immunogenetic differences and similarities of Sjögren's syndrome alone (primary) and Sjögren's syndrome associated with rheumatoid arthritis and systemic lupus erythematosus (secondary). The immunoregulation in Sjögren's syndrome is discussed and the incidence of immune complex-like material, its nature, pathophysiology, and clearance by the Fc receptor of the reticuloendothelial system presented.

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