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Amantadine: Does It Have a Role in the Prevention and Treatment of Influenza? A National Institutes of Health Consensus Development Conference

Ann Intern Med. 1980;92(2_Part_1):256-258. doi:10.7326/0003-4819-92-2-256
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Amantadine hydrochloride (Symmetrel is the Du-Pont registered trade name) is an antiviral compound currently approved in the United States for the prevention and symptomatic management of the respiratory tract illness caused by influenza A virus strains. The antiviral activity of amantadine was first reported 15 years ago, and its efficacy in the prophylaxis of type A influenza was shown in clinical trials over 10 years ago.

Amantadine was approved in 1966 for use in the prevention of Asian (H2N2) influenza. This use of the drug has not, however, received wide acceptance in the United States. The reluctance to use amantadine


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