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Diagnosis and Treatment |

Combination Antibiotic Therapy of Bacterial Endocarditis

MERLE A. SANDE, M.D.; and W. MICHAEL SCHELD, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Merle A. Sande, M.D.; Department of Medicine, University of Virginia; Charlottesville, VA 22908.


Charlottesville, Virginia


© 1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;92(3):390-395. doi:10.7326/0003-4819-92-3-390
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A penicillin-aminoglycoside regimen is accepted therapy for enterococcal endocarditis, but use of combinations of antibiotics in other forms of bacterial endocarditis is controversial. This review analyzes in-vitro, experimental animal model, and clinical studies of combination "synergistic" antibiotic treatment for enterococcal, viridans streptococcal, staphylococcal, and gram-negative aerobic bacillary endocarditis. Current recommendations for treatment of these entities are discussed.

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