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Characterization of the Glomerular Antibody in Acute Poststreptococcal Glomerulonephritis

BERNARDO RODRÍGUEZ-ITURBE, M.D.; DANA RABIDEAU, M.D.; RAFAEL GARCÍA, M.D.; LÍRIMO RUBIO, M.D.; and RAWLE M. McINTOSH, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Bernardo Rodrígues-Iturbe, M.D.; Renal Service, Hospital Universitario, Apartado Postal Central no. 1430; Maracaibo, Venezuela.


Maracaibo, Venezuela; and Denver, Colorado


© 1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;92(4):478-481. doi:10.7326/0003-4819-92-4-478
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Glomerular-fixed antibody was eluted from the kidney of a 17-year-old patient who died 2 weeks after the onset of acute poststreptococcal glomerulonephritis. Elevated titers of antibodies to streptococcal enzymes were found in the serum but not in the glomerular eluate. Streptococcal M protein and anti-M protein reactivity were not detected in the eluate. Immunoglobulin G was the only serum protein demonstrated in the eluate, and it was found to have anti-IgG activity highly concentrated with respect to the serum. These studies appear to indicate that anti-IgG is involved in the immune pathogenesis of acute poststreptococcal glomerulonephritis. Native IgG may be rendered autoimmunogenic by the streptococcus with subsequent antibody production to the neoautoimmunogen. Alernatively, anti-IgG may be produced to the IgG incorporated in an exogenous streptococcal antigen-antibody complex.

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