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Pulse Methylprednisolone Therapy in Idiopathic, Rapidly Progressive Glomerulonephritis

OLU OREDUGBA, M.D.; DEBESH C. MAZUMDAR, M.B., B.S.; JOHN S. MEYER, M.D.; and HERBERT LUBOWITZ, M.D.
[+] Article and Author Information

This paper was presented in part at the VIIth International Congress of Nephrology, 22 June 1978, Montreal, Canada.

Grant support: by U.S. Public Health Service grant HL06008.

▸Requests for reprints should be addressed to Debesh C. Mazumdar, M.B., B.S.; Mount Sinai Medical Center, 950 North 12th Street, P.O. Box 342; Milwaukee, WI 53201.


St. Louis, Missouri


© 1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;92(4):504-506. doi:10.7326/0003-4819-92-4-504
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Idiopathic crescentic glomerulonephritis is associated with a 70% to 80% incidence of end-stage renal failure. Oral corticosteroid therapy in combination with immunosuppressive agents or anticoagulants has not altered the prognosis of this disease. We have seen five adults with idiopathic crescentic glomerulonephritis and treated them with intravenous methylprednisolone. Before therapy, the average serum creatinine concentration was 7.4 ± 1.3 mg/dL (chi-square ± SEM). This value declined to 2.0 ± 0.48 mg/dL within 4 weeks. All patients continue to maintain stable renal function over an average follow-up period of 19 months (range, 1.5 to 36 months). These data suggest that a prospective controlled trial of this therapy is warranted in the management of this entity.

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