0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

The Progression of Vesicoureteral Reflux Nephropathy

VICENTE E. TORRES, M.D.; JORGE A. VELOSA, M.D.; KEITH E. HOLLEY, M.D.; PANAYOTIS P. KELALIS, M.D.; GUNNAR B. STICKLER, M.D.; and STEPHEN B. KURTZ, M.D.
[+] Article and Author Information

Dr. Velosa is recipient of Clinical Investigator Award AM 00662, National Institute of Arthritis, Metabolism, and Digestive Diseases.

Presented at the 12th Annual Meeting of the American Society of Nephrology, 18-20 November 1979, Boston, Massachusetts.

▸Requests for reprints should be addressed to Vicente E. Torres, M.D.; c/o Section of Publications, Mayo Clinic, 200 First Street SW; Rochester, MN 55901.


Rochester, Minnesota


© 1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;92(6):776-784. doi:10.7326/0003-4819-92-6-776
Text Size: A A A

The relations among renal function, proteinuria, and glomerular lesions were studied in 54 patients with reflux nephropathy. The clinical course to end-stage renal disease was not appreciably altered by late surgical correction of the reflux, occurrence of urinary tract infection, or hypertension. All patients with progressive renal disease had significant proteinuria. Mesangial glomerular lesions can occur in the absence of proteinuria detectable by routine urinalysis, whereas lesions similar to those seen in idiopathic focal sclerosing glomerulopathy were present in the renal biopsies from proteinuric patients. Deposition of immunoproteins was limited to glomeruli undergoing sclerosis. Similarly, electron-dense deposits were confined to areas of mesangial alterations. Our results suggest that mesangial alterations occur early in the course of reflux nephropathy and may lead to the development of focal sclerosis. At later stages, counterproductive mechanisms of adaptation to the loss of viable nephrons might result in an acceleration of the clinical course to renal failure.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)