0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Cyclophosphamide, Vincristine, Methotrexate with Leucovorin Rescue, and Cytarabine (COMLA) Combination Sequential Chemotherapy for Advanced Diffuse Histiocytic Lymphoma

DONALD L. SWEET, M.D.; HARVEY M. GOLOMB, M.D.; JOHN E. ULTMANN, M.D.; J. BRUCE MILLER, M.D.; RICHARD S. STEIN, M.D.; ERIC P. LESTER, M.D.; URI MINTZ, M.D.; JACOB D. BITRAN, M.D.; ROLF A. STREULI, M.D.; KAREN DALY, R.N.; and NINO O. ROTH, R.N.
[+] Article and Author Information

Grant support: in part by U. S. Public Health Service grants CA 14599, CA 16401, and PHD 1-T32-AM07134-01 and by The Joanne Heppes Fund, The Goldblatt Brothers Employees Nathan Goldblatt Cancer Research Fund, The Kathy Shaheen Fund, and The Jean Heiman Fund. Dr. Sweet is a junior faculty clinical fellow of The American Cancer Society.

The Franklin McLean Memorial Research Institute is operated by The University of Chicago for the U.S. Department of Energy under contract EY 76-C-02-0069.

▸Requests for reprints should be addressed to Donald L. Sweet, M.D.; Department of Medicine, The Pritzker School of Medicine, Box 240, 950 E. 59th Street; Chicago, IL 60637.


Chicago, Illinois


© 1980 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1980;92(6):785-790. doi:10.7326/0003-4819-92-6-785
Text Size: A A A

A program of combination sequential chemotherapy using cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine (COMLA) was administered to 42 previously untreated patients with advanced diffuse histiocytic lymphoma. Twenty-three patients achieved a complete remission as determined by strict clinical restaging criteria. The observed median duration of survival for the complete responders is longer than 33 months. Eight patients achieved a partial response, with a median survival longer than 21 months. Eleven patients showed no response, with a median survival of 5 months. Toxicity was acceptable. None of the responders have shown central nervous system relapse. There was no difference in response rates between patients with stage III or IV lymphoma or between asymptomatic or symptomatic patients. The COMLA program produces a high rate of complete and durable remissions and should be considered as an initial form of management of patients with advanced diffuse histiocytic lymphoma.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)